Blood Pressure Variability And Shifting In Clinical Outcome Amongst Stroke Patients Admitted To Mbarara Regional Referral Hospital.

Authors

  • Nicholas Kulaba Mbarara University of Science and technology, Uganda.
  • Adrian Kayanja Mbarara University of Science and technology, Uganda.
  • Denis Serubiri
  • Shirley Moore
  • Mark Kaddu Mukasa Mbarara University of Science and technology, Uganda.
  • Cumara O’Carroll
  • Anthony Muyingo Mbarara University of Science and technology, Uganda.

Abstract

Background: Greater blood pressure variability can have detrimental effects on clinical outcome after a stroke and it’s has not been evaluated in Sub-Saharan Africa (SSA). Methods: We conducted a prospective cohort study of CT head confirmed ischemic and hemorrhagic stroke admitted within 7 days of onset of motor weakness. Blood Pressure Variability (BPV) indices; Standard Deviation (SD) and coefficient of variation (CV) of systolic and diastolic Blood pressure (BP) between 0 and 7 days after admission were calculated with subsequent modified Rankin Scale (mRS) score on day 14  and day 30 post-stroke. Ordinal logistic regression was fitted to determine the adjusted odds ratios (aOR) for shifting towards bad functional outcome among patients with stroke that had survived beyond 14 days with 95% CI and p value<0.05 used as statistical significance. Results: Out of 120 patients, 31 patients passed on by day 14, 89 patients survived beyond day 14. 58 and 15 patients had a zero and 1 point shift in MRS towards bad outcome respectively. SD systolic BP tertiles (2&3) had aOR: 1.6, p= 0.306 (95%C.I: 0.6-4.1) and 5.8, p = 0.002 (95%C.I: 1.9-17.5) respectively. CV systolic BP tertiles (3&2) had aOR=2.9, p= 0.045 (95% CI: 1.0 – 8.3) and 1.4, p= 0.615 (95% CI: 0.4 - 4.5) respectively. NIHSS≥16 had aOR=3.8 (95%CI: 1.5-9.6) P=0.004 and time to presentation ≥ 3 days had aOR=2.8 (95% C.I:1.2-6.3) p=0.013. Conclusion: High BPV (SDSBP & CVSBP tertile 3), late presentation ≥ 3 days and high NIHSS conferred statistically significant odds of shifting towards a bad functional outcome.

Published

06-12-2022

How to Cite

1.
Kulaba N, Kayanja A, Serubiri D, Moore S, Mukasa MK, O’Carroll C, et al. Blood Pressure Variability And Shifting In Clinical Outcome Amongst Stroke Patients Admitted To Mbarara Regional Referral Hospital. EAJNS [Internet]. 2022 Dec. 6 [cited 2024 Feb. 27];1(Supp 2). Available from: https://theeajns.org/index.php/eajns/article/view/66

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Section

Conference Abstracts

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