Mood Disorders Associated With Pituitary Adenoma: Review of Literature



pituitary adenoma, Mood disorders, Depression, anxiety, ACTH, Prolactinoma, apathy, TSH, neuropsychiatry


Pituitary adenomas are linked to various mood disorders, including depression, mania, and anxiety disorders. Additionally, these adenomas have been observed to present other psychiatric symptoms, such as eating disorders and suicidal ideation. A thorough literature review was conducted, utilizing diverse search engines, including PubMed, Cochrane, and Google Scholar. The search terms used included "pituitary adenomas," "mood disorders," "Hypothalamo-pituitary axis," "hypopituitarism," "acromegaly," "depression," "mania," and "psychosis." The selected publications comprised case reports and pertinent research articles. There is a high prevalence of comorbidity between pituitary adenomas and depressive and anxiety disorders. The manifestation of these symptoms can be attributed to the endocrine dysfunction associated with pituitary adenomas, as well as the physical impact and tumor growth. Furthermore, it has been noted that apathy syndrome and chronic fatigue syndrome may be misdiagnosed as depression among individuals in this specific patient demographic. The presence of mood disorders can influence the process of diagnosing and treating pituitary adenomas. Diseases of this nature can potentially affect patients' daily functioning and their ability to engage in social activities. These individuals require appropriate medical intervention to improve their prognosis.

Author Biography

Dr. M A Magoha, Department of Surgery, University of Nairobi

Neurological Surgeon, Lecturer Department of Surgery (University Of Nairobi)


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How to Cite

Nageyle FM, Magoha MA. Mood Disorders Associated With Pituitary Adenoma: Review of Literature. EAJNS [Internet]. 2024 Jan. 30 [cited 2024 Jul. 25];3(1):27-3. Available from:



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