Treatment Response Utilizing CSF IL 1 Beta Level In Bacterial Meningitis Patients
Schlagwörter:
bacterial meningitis; CSF; outcome; treatment response; IL-6Abstract
Background: Bacterial meningitis is a serious infectious disease that is mainly caused by the inflammatory reaction. This inflammation leads to the release of biomarkers into the cerebrospinal fluid (CSF). Aim: The study aimed to evaluate the levels of IL-1β in the cerebrospinal fluid (CSF) during the acute phase and on day 14 after treatment, as well as to investigate their correlation with clinical outcomes. Methods: This prospective observational study included 40 patients with bacterial meningitis treated at Alexandria Fever Hospital between January and December 2021. Patients were classified according to outcome (death, complete recovery, or complicated course). Clinical, laboratory and radiological parameters were recorded, and CSF IL-1β was measured by ELISA at baseline and day 14. Result: Baseline CSF IL-1β was significantly higher among patients with poor outcomes (p = 0.01). Day-14 levels showed no statistically significant association with outcome. Conclusion: Higher acute-phase CSF IL-1β is associated with adverse outcomes in bacterial meningitis, whereas post-treatment levels are non-discriminatory. Larger, methodologically robust studies are required for validation.
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